Skip to main content

Table 1 Differential gene expression of C. glutamicum caused by ciprofloxacin

From: Ciprofloxacin triggered glutamate production by Corynebacterium glutamicum

Gene IDa

Gene namea

Function of proteina

M-valueb

P-value*

DNA synthesis, repair, modification

 cg2141

recA

Recombinase A

3.86

0.000

 cg1996

cglIM

DNA (cytosine-5-)-methyltransferase

3.41

0.000

 cg0886

-

Putative ATP-dependent DNA helicase superfamily II

2.41

0.003

 cg1401

ligA

DNA ligase (NAD(+))

2.16

0.002

 cg1400

-

Putative DNA polymerase III, Gram-positive-type alpha subunit

2.01

0.002

 cg1997

cglIR

Putative type II restriction endonuclease

1.38

0.001

 cg0885

-

Putative helicase, UvrD/Rep-family

1.08

0.029

 cg2509

recO

DNA repair protein RecO

1.05

0.044

 cg1316

-

DNA/RNA helicase, SNF2 family

1.03

0.022

 cg1018

-

Putative ATP-dependent DNA helicase

3.12

0.001

 cg2950

radA

Putative ATP-dependent protease involved in DNA repair

1.10

0.029

Transcription, Translation, Proteinmodification

 cg2114

lexA

transcriptional regulator, LexA-family

1.61

0.004

 cg3071

pyrE

Orotate phosphoribosyltransferase

1.38

0.025

 cg0684

papA

Prolyl aminopeptidase A

1.31

0.006

 cg0685

-

Conserved hypothetical protein similar to metal-dependent proteases, putative molecular chaperone

1.66

0.003

 cg0686

-

Putative acetyltransferase, GNAT-family

1.32

0.013

 cg1980

-

Hypothetical protein, MoxR-like ATPase

1.33

0.006

Genes of unknown function

 cg2113

divS

Cell division suppressor DivS

5.38

0.000

 cg2381

-

Conserved hypothetical protein

3.86

0.000

 cg1287

-

Conserved hypothetical protein

3.09

0.008

 cg1962

-

Putative membrane protein

2.56

0.000

 cg0839

-

Hypothetical protein

2.52

0.001

 cg1977

-

Putative secreted protein

1.95

0.000

 cg2026

-

Hypothetical protein

1.88

0.000

 cg1978

-

Hypothetical protein

1.72

0.000

 cg1917

-

Hypothetical protein

1.50

0.002

 cg0841

-

Conserved hypothetical protein

1.39

0.016

 cg1743

-

Conserved hypothetical protein

1.38

0.006

 cg1937

-

Putative secreted protein

1.22

0.015

 cg3018

-

Hypothetical protein

1.22

0.002

 cg0451

-

Putative membrane protein

1.21

0.003

 cg0712

-

Putative secreted protein

1.08

0.014

 cg3106

-

Conserved hypothetical protein

1.03

0.029

 cg2391

aroG

3-Deoxy-7-phosphoheptulonate synthase

-1.26

0.022

 cg0203

iolE

Putative myo-inosose-2 dehydratase

-1.25

0.009

 cg1342

narJ

Respiratory nitrate reductase 2, delta chain

-1.13

0.041

 cg2378

mraZ

Putative MraZ protein

-1.13

0.023

 cg2118

fruR

transcriptional regulator of fructose metabolism

-1.08

0.014

 cg0205

iolH

Myo-inositol catabolism protein

-1.06

0.044

Genes of unknown function

 cg1918

-

Putative secreted protein

-2.82

0.000

 cg2080

-

Conserved hypothetical protein

-1.74

0.012

 cg2952

-

Putative secreted protein

-1.58

0.002

 cg0045

-

ABC-type putative sugar transporter, permease subunit

-1.36

0.025

 cg1884

-

Putative membrane protein

-1.30

0.038

 cg1340

-

Conserved hypothetical protein

-1.27

0.001

 cg3226

-

Putative MFS-type L-lactate permease

-1.15

0.009

  1. aGene ID, gene name and function of proteins are given according to CoryneRegNet (http://coryneregnet.de). bRelative RNA levels of cells treated with 4 μg∙ml-1 ciprofloxacin compared to untreated cells are shown as log 2 values (M-values). * P-values were determined by Student’s t-test. Only genes with significant (p < 0.05) expression differences and M-values >1 or <1 are listed. The wild type was cultured in triplicate in CGXII with 1 % (w/v) glucose to an OD600 of about 5. Afterwards, cells were exposed to 4 µg/ml ciprofloxacin, a concentration allowing minor growth of the cultures. The data are available as Gene Expression Omnibus GSE77189 data set at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/geo/
Back to article page

BMC Microbiology

ISSN: 1471-2180

Contact us