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Table 1 Comparison of the Line Probe Assay with the Reference PCR for bacterial meningitis in CSF samples

From: Evaluation of the line probe assay for the rapid detection of bacterial meningitis pathogens in cerebrospinal fluid samples from children

LPA results

Reference PCR results

(n)

 
 

Negative

Sp

Hib

Men

Hi

lytA Eq

hpd Eq

ctrA Eq

Total

Negative

380

24

1

6

2

12

4

2

431

Sp

30

92

0

0

0

5

0

0

127

Hib

15

3

35

0

0

0

0

0

53

Men

4

2

0

35

0

0

0

0

41

16S DNA

92

2

0

0

0

1

0

0

95

Double banding Sp or Hib

0

0

1

1

0

0

0

0

2

Double banding Hib or Men

1

1

0

0

0

0

0

0

2

Not done

73

7

3

5

1

1

0

0

90

Total

595

131

40

47

3

19

4

2

841

  1. LPA line probe assay, Sp Streptococcus pneumoniae, Hib H. influenzae type b, Men N. meningitidis, Hi non-typeable H. influenzae, lytA Eq equivocal for ltyA, hpd Eq equivocal for hpd, ctrA Eq equivocal for ctrA