Table 2 An example of translational efficiencies of HCV IRESs containing variations of some hypervariable and/or conserved nucleotides as revealed from the HCVIVdb data analysis

Hypervariable nucleotides

Translational activity %

References

A 204 C

~100

[20]

C 204 U

109 ± 9

[22]

C 204 U

~80

[21]

U 204 A

Retains full activity

[23]

A 243 G

92

[20]

G 203 A + G 243 A

100

[20]

C 204 A + G 243 A

83

[21]

Conserved nucleotides

Translational activity %

References

G 266 A

5

[25]

G 266 C

3

[23]

G 267 C

>95 reduction in activity

[24]

G 267 C

2

[23]

G 268 C

>95 reduction in activity

[24]

G 268 C

3

[23]