Fig. 1

Proposed domain organization of ClpB from L. interrogans. a The diagram shows structural domains of the protein: N-terminal domain (ND) with the double Clp_N motif, nucleotide binding domain 1 (NBD1), middle coiled-coil domain (MD) and nucleotide binding domain 2 (NBD2). Conserved ATPase motifs such as the Walker A (A), Walker B (B), sensor 1, sensor 2 (GAR) and the Arg fingers (R), coordinating ATP binding and hydrolysis are also indicated. Conserved residues of these motifs are marked in bold. b Sequence alignment of ClpB from E. coli (B_Ec) and L. interrogans (B_Li). Domain boundaries are indicated below the amino acid sequence. The conserved motifs are shown in red. Identical and similar amino acid resides are shaded in black and gray, ... respectively