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Fig. 4 | BMC Microbiology

Fig. 4

From: Antifungal activity of Myriocin on clinically relevant Aspergillus fumigatus strains producing biofilm

Fig. 4

Ultrastructural imaging of A. fumigatus Af293 biofilm morphology treated or not with Myriocin (4 mg/L). a 48h untreated biofilm: normal fungal cells morphology (12000X original magnification -o.m.; Bar = 600 nm); b 4h post-Myriocin: the fungal cell showed some alterations of the inner membrane that became non homogeneous (12000X o.m.; Bar = 600 nm); c 24h post-Myriocin: the plasma membrane showed several disorganized invaginations associated with cell wall detachment (20000X o.m.; Bar = 400 nm); d 24h post-Myriocin: the hyphae showed a cell wall collapsed, and a degenerated cytoplasm highly vacuolarized; none of the cell organelles was recognizable. (12000X o.m.; Bar = 600 nm); e 48h post-Myriocin: a large part of the fungal cells is damaged and disrupted (12000X o.m.; Bar = 2.5 μm)

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