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Fig. 6 | BMC Microbiology

Fig. 6

From: Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus

Fig. 6

Effect of thioridazine on the ciprofloxacin MIC for the strains exposed to EP substrates. MIC values were determined for each strain prior to exposure (P0) and after each exposure process (P20) in the absence (green columns) and in the presence (orange columns) of the efflux inhibitor thioridazine (TZ) at the sub-inhibitory concentration of 12.5 mg/L. The strain ATCC25923 exposed to the ciprofloxacin MIC was the single one in which a fluoroquinolone-resistance mutation (S80F in the QRDR region of GrlA) occurred during an exposure process (red star). The breakpoint for considering intermediate resistance to ciprofloxacin (according to CLSI guidelines) is represented by a blue dashed line

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