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Table 2 Proteins identified in the secretome of C. neoformans collected at 96 hpi from cells grown in Pka1-repressed (glucose-containing medium) conditions

From: Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A

GO categoriesa

Accession number

Protein name

Fold changeb

Std. Dev.

Carbohydrate catabolic process

 

CNAG_02189

α-Amylase

0.777

0.019

GTP catabolic process

 

CNAG_06125

Translation elongation factor 1 α

2.062

2.181

Carbohydrate metabolic process

 

CNAG_02860

Endo-1,3(4)-β-glucanase

0.947

0.583

 

CNAG_06501

1,3-β-glucanosyltransferase

0.968

0.100

 

CNAG_05799

Chitin deacetylase

1.439

0.775

 

CNAG_06291

Deacetylase

1.464

0.778

 

CNAG_01239

Chitin deacetylase

2.014

0.584

Cellular carbohydrate metabolic process

 

CNAG_03225

Malate dehydrogenase

0.472

0.546

Pentose-phosphate pathway

 

CNAG_07561

Phosphogluconate dehydrogenase

>10

>10

Protein ubiquitination

 

CNAG_01920

Polyubiquitin

1.261

0.396

ATP hydrolysis coupled proton transport

 

CNAG_05918

F0F1 ATP synthase subunit β

0.451

0.249

 

CNAG_05750

ATPase α subunit

0.604

0.387

Transmembrane transport

 

CNAG_06101

Eukaryotic ADP/ATP carrier

7.524

9.753

Methionine biosynthetic process

 

CNAG_01890

5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase

0.778

0.327

Dephosphorylation

 

CNAG_02944

Acid phosphatase

1.862

0.083

Glycolysis

 

CNAG_03072

Phosphopyruvate hydratase

3.093

3.377

Oxidation-reduction process

 

CNAG_01019

Cu/Zn superoxide dismutase

0.302

0.161

 

CNAG_03465

Laccase

0.718

0.668

Proteolysis

 

CNAG_00919

Carboxypeptidase D

4.664

5.261

Response to stress

 

CNAG_01727

Hsc70-4

1.883

2.094

Translation

 

CNAG_06095

Ribosomal protein L13

0.147

0.057

Unknown/Unclassified

 

CNAG_01653

Cytokine-inducing glycoprotein

0.134

0.158

 

CNAG_00407

Glyoxal oxidase

0.719

0.230

 

CNAG_04291

Glycosyl-hydrolase

0.583

0.287

 

CNAG_02030

Glyoxal oxidase

0.513

0.109

 

CNAG_06267

Rds1 protein

3.409

0.106

Hypothetical

 

CNAG_05312

Conserved hypothetical protein

0.341

0.100

 

CNAG_03007

Conserved hypothetical protein

0.518

0.649

 

CNAG_01562

Conserved hypothetical protein

0.942

0.194

 

CNAG_05893

Conserved hypothetical protein

0.991

0.487

 

CNAG_01047

Conserved hypothetical protein

6.714

6.494

 

CNAG_00588

Conserved hypothetical protein

>10

>10

 

CNAG_03223

Conserved hypothetical protein

>10

>10

 

CNAG_00586

Conserved hypothetical protein

>10

>10

  1. aProteins were categorized based on GO terms associated with their biological classification
  2. bFold change is reported as the average quantification for P GAL7 ::PKA1 vs. WT, ± standard deviation
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BMC Microbiology

ISSN: 1471-2180

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