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Table 1 Proteins identified in the secretome of C. neoformans collected at 16, 48, 72, and 120 hpi grown in Pka1-repressed (glucose-containing medium) and Pka1-induced (galactose-containing medium) conditions

From: Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A

GO categoriesa

Accession number

Protein Name

 

Fold changeb*

Std. Dev.

Time point

Pka1-repression

Pka1-induction

Pka1-repression

Pka1-induction

Carbohydrate catabolic process

     
 

CNAG_02189

α-Amylase

16 hpi

0.298

1.096

0.314

1.270

GTP catabolic process

      
 

CNAG_06125

Translation elongation factor 1 α

16 hpi

0.135

0.379

0.145

0.517

Carbohydrate metabolic process

     
 

CNAG_01239

Chitin deacetylase

16 hpi

0.906

1.350

0.310

0.515

 

CNAG_04245

Chitinase

16 hpi

0.448

0.286

0.007

0.296

   

48 hpi

0.826

0.603

1.019

0.017

 

CNAG_06501

1,3-β-glucanosyltransferase

16 hpi

0.573

0.896

0.383

0.169

Transmembrane transport

      
 

CNAG_02974

Voltage-dependent ion-selective channel

16 hpi

0.223

0.466

0.089

0.645

Oxidation-reduction process

      
 

CNAG_03465

Laccase

16 hpi

0.637

0.870

0.651

1.038

Unknown/Unclassified

      
 

CNAG_02030

Glyoxal oxidase

16 hpi

0.278

0.600

0.324

0.672

   

48 hpi

0.242

0.350

0.063

0.144

 

CNAG_06267

Rds1 protein

16 hpi

0.336

0.756

0.303

0.222

   

120 hpi

0.860

5.106

0.444

4.588

 

CNAG_00776

Immunoreactive mannoprotein MP88

16 hpi

0.627

0.994

0.214

1.193

 

CNAG_02864

Predicted protein

16 hpi

0.346

0.259

0.056

0.183

 

CNAG_04753

Lactonohydrolase

16 hpi

1.031

0.751

0.631

0.413

   

48 hpi

1.250

1.055

0.996

0.546

Hypothetical

      
 

CNAG_00587

Hypothetical protein

16 hpi

1.275

1.620

0.018

0.371

 

CNAG_01047

Hypothetical protein

16 hpi

0.279

0.471

0.070

0.272

   

72 hpi

0.928

0.719

1.034

0.432

 

CNAG_03492

Hypothetical protein

16 hpi

0.506

0.799

0.400

0.030

   

72 hpi

0.640

1.180

0.199

0.431

 

CNAG_05893

Hypothetical protein

48 hpi

1.609

1.676

1.380

1.639

   

120 hpi

1.641

1.413

0.953

0.348

  1. aProteins were categorized based on GO terms associated with their biological classification
  2. bFold change is reported as the average quantification for P GAL7 ::PKA1 vs. WT, ± standard deviation
  3. *Statistical analysis was performed using a Student’s t-test between the conditions. None of the comparisons resulted in a significant difference in protein abundance (p-value > 0.05)