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Table 2 QS and virulence genes regulated by AI-2 of P. aeruginosa biofilm

From: Autoinducer-2 regulates Pseudomonas aeruginosa PAO1 biofilm formation and virulence production in a dose-dependent manner

Gene

Fold change in expression

0

0.1 nM

1 nM

10 nM

100 nM

1 μM

lasI

1

1.9 ± 0.1

2.7 ± 0.2*

3.3 ± 0.2*

2.2 ± 0.18*

2 ± 0.2*

lasR

1

1.3 ± 0.1

1.9 ± 0.16

2.1 ± 0.23*

1.3 ± 0.16

1.3 ± 0.2

rhlI

1

1.5 ± 0.17

2.1 ± 0.1*

2.3 ± 0.13*

1.7 ± 0.16

1.2 ± 0.1

rhlR

1

2.1 ± 0.2*

3.4 ± 0.3*

3.5 ± 0.24*

2.2 ± 0.13*

1.8 ± 0.3

lasA

1

4.3 ± 0.16*

5.1 ± 0.27*

11 ± 0.21*

4 ± 0.21*

3 ± 0.18*

lasB

1

4 ± 0.14*

5.8 ± 0.45*

12.7 ± 1.7*

5 ± 0.15*

2.8 ± 0.13*

phzH

1

3.6 ± 0.34*

5.8 ± 0.67*

10.6 ± 0.7*

3.8 ± 0.16*

3.3 ± 0.22*

rhlA

1

2.2 ± 0.16*

3.7 ± 0.33*

4.8 ± 0.56*

2.3 ± 0.14*

2.1 + 0.14*

  1. Values marked with an asterisk (*) indicate that the fold change of relative gene expression level of P. aeruginosa PAO1 in the presence of different concentrations of AI-2 was significantly different from negative control at P < 0.05