Fig. 5

Susceptibility of C57BL/6 mice to infection with DENV. The animals were infected with D3/BR/SL3/02 (n = 5) (a, b and c) and D2/BR/RP/RMB/2009 (n = 5) (a, d and e) isolates, and Mochizuki strain (n = 5) (a, f and g). The infection was confirmed by detection of the virus genome by real-time RT-PCR in serum (a) and different organs (b-g). The animals were infected with D3/BR/SL3/02 and D2/BR/RP/RMB/2009 (n = 5) isolates, and Mochizuki strain, which were incubated with PBS (b, d and f, respectively) or enhancing antibodies (c, e and g, respectively). Data represent the mean values ± SD. The results are representative of two similar and independent experiments. *p < 0.05 when viruses incubated with heterologous immune sera were compared to viruses incubated with PBS