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Table 4 Invasive Neisseria meningitidis from Québec, Canada in 2009-2013: predicted vaccine coverage based on at least one antigen showing an exact match to the 4CMenB vaccine components or with Novartis variant 1 factor H binding protein (fHbp)/Neisseria adhesin A (NadA) peptides belonging to variants 1 to 3

From: Characterization of invasive Neisseria meningitidis strains from Québec, Canada, during a period of increased serogroup B disease, 2009-2013: phenotyping and genotyping with special emphasis on the non-carbohydrate protein vaccine targets

 

Predicted coverage based on exact match to 4CMenB componentsa

CC

ST

Serogroup

# of isolates

fHbpb

NHBA

NadA-2/3c

PorA

ST-41/44

ST-41

B

1

Possibly, 4

Yes

No

Yes

 

ST-154

B

1

Possibly, 4

Yes

No

Yes

 

ST-41

B

1

Possibly, 4

Yes

No

No

 

ST-1194

B

1

Possibly, 4

Yes

No

No

 

ST-8052

B

1

Possibly, 14

Yes

No

No

 

ST-10619

B

1

Possibly, 100

Yes

No

No

ST-32 CC

ST-32

B

2

Yes, 1

Unknown

No

No

ST-174 CC

ST-1466

Y

1

No

Unknown

8

No

Additional coverage based on strains predicted to express NadA-1,2/3 and/or Novartis variant 1 fHbp peptides

ST-269 CC

ST-269

B

143

Possibly, 15

Unknown

No

No

 

ST-1986

B

4

Possibly, 15

Unknown

No

No

 

ST-5494

B

3

Possibly, 15

Unknown

No

No

 

ST-8767

B

1

Possibly, 15

Unknown

No

No

 

ST-8880

B

1

Possibly, 15

Unknown

No

No

 

ST-2738

B

1

Possibly, 249

Unknown

No

No

ST-32 CC

ST-33

B

1

Possibly, 144

Unknown

85

No

 

ST-2726

B

2

No

Unknown

1

No

ST-35 CC

ST-278

B

1

Possibly, 4

Unknown

No

No

ST-1157 CC

ST-1157

B

2

Possibly, 13

Unknown

No

No

ST-60 CC

ST-10587

B

1

Possibly, 13

Unknown

No

No

ST-254 CC

ST-10332

B

1

Possibly, 13

Unknown

No

No

Not assignedd

ST-336

B

1

No

Unknown

3

No

 

ST-7655

B

1

Possibly, 13

Unknown

No

No

 

ST-7704

B

1

Possibly, 110

Unknown

No

No

 

ST-9248

B

1

Possibly, 12

Unknown

No

No

ST-11 CC

ST-11

C

2

No

Unknown

3

No

 

ST-11

C

1

No

Unknown

2

No

 

ST-11

C

1

Possibly, 12

Unknown

No

No

 

ST-11

C

1

Possibly, 129

Unknown

No

No

 

ST-11

C

1

Possibly, 218

Unknown

No

No

ST-167 CC

ST-6171

Y

1

Possibly, 278

Unknown

No

No

  1. a4CMenB vaccine components include: factor H binding protein (fHbp) peptide 1; Neisseria Heparin Binding Antigen (NHBA) peptide 2; Neisseria adhesion A (NadA)-2/3 peptide 8; and outer membrane protein porin A (PorA) P1.4
  2. bNovartis variant 1 peptides were indicated by their peptide number possibly covered by the vaccine; whereas variants 2/3 peptides were labelled as No to indicate no match or not covered by the 4CMenB vaccine
  3. cNadA variant 1-3 peptides were indicated by their peptide number; whereas No was used to indicate absence of the nadA gene
  4. dNot assigned to any known clonal complex according to the current Neisseria MLST website (http://pubmlst.org/neisseria/)