Figure 5From: Soluble factors from biofilms of wound pathogens modulate human bone marrow-derived stromal cell differentiation, migration, angiogenesis, and cytokine secretion Soluble factors from biofilms increase release of wound healing cytokines from hBMSCs. Quantification of inflammatory cytokines TNF-α (A) and IL-6 (B), wound healing cytokines SDF-1 (C) and VEGF (D), and antimicrobial peptide LL-37 (E) in cell supernatants (media) by ELISA analysis following hBMSC exposure to BCM (25%) for 1 and 3 days. Protein levels were normalized, expressed as a ratio of specific cytokine concentration to total protein content (μg/mL, quantified via a bicinchoninic acid assay); *,# p < 0.05 compared to day 1 and 3 growth control, respectively.Back to article page