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Table 4 Differentially expressed miRNAs identified to be commonly presented in mouse lungs infected either with w81 or ma81 at 3 dpi

From: Differential microRNA expression following infection with a mouse-adapted, highly virulent avian H5N2 virus

miRNA

w81‡

ma81‡

3dpi

3dpi

Fold change*

P value§

Fold change

P value

miR-100-5p†

2.6

0

2

0.007

miR-130a-5p†

3.2

0.01

2.2

0.03

miR-132-3p

3.3

0.01

3.6

0

miR-132-5p

2.6

0.015

2.7

0.049

miR-146b-5p

3.6

0.004

3.2

0.009

miR-146b-3p†

4.7

0.003

4.1

0.046

miR-147-3p†

22.8

0.012

25.2

0.04

miR-151-5p†

2.7

0.014

2.2

0.002

miR-154-3p

4.8

0.001

3.5

0.031

miR-155-3p†

3.5

0.016

6.2

0.018

miR-1943-3p

4.3

0.049

3.3

0.033

miR-212-3p

3.7

0

3.6

0.048

miR-214-3p

3

0.007

2.6

0.026

miR-223-3p†

3.4

0.009

8.9

0.013

miR-27a-5p

3.9

0.001

2.9

0.023

miR-29b-1-5p

2.1

0.037

2.2

0.021

miR-301a-3p†

−2

0.048

−2

0.049

miR-361-3p

2.6

0.032

2.3

0.009

miR-495-3p†

2.9

0.01

2.3

0.004

miR-652-3p

2.8

0.011

2.7

0.032

  1. ‡ global cellular miRNA expression patterns in mouse lungs infected either with w81 or ma81 were compared with those of uninfected control mouse lungs. Differentially expressed miRNAs with a p < 0.05 and fold change>2 are described.
  2. *Sequence reads were normalized to determine the number of transcripts per million (TPM) using the following formula: Normalized expression = Actual miRNA count/Total count of clean reads*1000000. Then, fold changes of miRNAs were evaluated using the following formula: Fold change = log2 (treatment/control).
  3. §P-value was calculated from the normalized expression values as previously described [66].
  4. °Commonly upregulated at both 1 and 3 dpi.