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Table 1 Lethal dose 50% of H. pylori strains in Galleria mellonella

From: Use of larvae of the wax moth Galleria mellonella as an in vivo model to study the virulence of Helicobacter pylori

 

LD50(means ± SEM)*

Strains

48 h

72 h

G27

2.8 (±0.4) × 105

2.4 (±0.2) × 105

G27Δcag A

 

3.1 (±0.04) × 106

G27Δcag E

 

2.4 (±0.06) × 106

G27ΔcagPAI

 

2.0 (±0.01) × 106

60190

6.1 (±0.4) × 105

1.4 (±0.04) × 106

60190ΔvacA

 

8.2 (±0.04) × 106

60190ΔcagA

 

9.7 (±0.04) × 106

60190ΔcagE

 

9.5 (±0.06) × 106

60190Urease-negative

 

8.7 (±0.04) × 106

M5

12.8 (±0.3) × 105

2.1 (±0.08) × 105

M5 ggt::aph

12.0 (±0.6) × 105

1.0 (±0.1) × 105

  1. *The LD50 values were expressed in Colony Forming Units (CFUs).