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Table 2 Effect of phage on adhesion, invasion and cytotoxicity of NEC by additional clinical strains of S. aureus (MRSA)

From: Bacteriophage as effective decolonising agent for elimination of MRSA from anterior nares of BALB/c mice

Strains (Bacteria: NEC- 10:1)

Mean percent (%)

Adherence

Invasion

Cytotoxicity (24 h)

No phage

Phage (MOI-1)

Phage (MOI-10)

No phage

Phage (MOI-1)

Phage (MOI-10)

No phage

Phage (MOI-1)

Phage (MOI-10)

S. aureus ATCC 43300 (MRSA)

73.7

0.41

0.025

31.9

0.031

No invasion

11.1

0.21

No cytotoxicity

S. aureus ATCC 29213 (MSSA)

76.8

0.51

0.034

18.4

0.034

No invasion

10.2

0.23

No cytotoxicity

S. aureus CS-1

68.4

0.37

0.066

28.1

0.06

No invasion

11.4

0.41

No cytotoxicity

S. aureus CS-2

62.5

0.32

0.074

25.4

0.064

No invasion

10.1

0.43

No cytotoxicity

S. aureus CS-3

74.8

0.45

0.084

33.3

0.078

No invasion

14.5

0.64

No cytotoxicity

S. aureus CS-4

70.4

0.34

0.081

30.4

0.072

No invasion

14

0.61

No cytotoxicity

S. aureus CS-5

72.1

0.33

0.075

32.8

0.066

No invasion

13.3

0.72

No cytotoxicity

  1. (CS-1 to CS-5 : these are clinical strains (CS) of MRSA chosen at random to test for their adherence, invasion and cytotoxicity parameters on cultured murine NEC).