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Table 5 Regulators and factors involved in virulence and/or resistance subject to regulation by CcpA and glucose

From: Effect of a glucose impulse on the CcpA regulon in Staphylococcus aureus

ID

 

Producta

wt

mut

N315

Newman

common

 

+/-b

+/-b

Glucose-dependent regulation by CcpA

Down-regulated by glucose

*SA0107

NWNM_0055

spa

immunoglobulin G binding protein A precursor

0.2

1.1

SA0620

NWNM_0634

 

secretory antigen SsaA homologue

0.4

0.9

SA0841

NWNM_0851

 

similar to cell surface protein Map-w

0.4

0.9

SA0905

NWNM_0922

atl

autolysin (N-acetylmuramyl-L-alanine amidase and endo-b-N-acetylglucosaminidase)

0.4

1.1

SA2353

NWNM_2466

 

similar to secretory antigen precursor SsaA

0.5

1.0

SA2356

NWNM_2469

isaA

immunodominant antigen A

0.4

0.8

Up-regulated by glucose

SA1010

NWNM_1076

 

similar to exotoxin 4

2.3

0.6

SA1700

NWNM_1822

vraR

two-component response regulator

2.2

0.8

SA1701

NWNM_1823

vraS

two-component sensor histidine kinase

2.5

0.7

SA1869

NWNM_1970

sigB

sigma factor B

1.7

1.0

SA1870

NWNM_1971

rsbW

anti-sigmaB factor

2.2

1.1

SA1871

NWNM_1972

rsbV

anti-sigmaB factor antagonist

1.3

0.9

SA1872

NWNM_1973

rsbU

sigmaB regulation protein RsbU

0.9

0.7

SA2290

NWNM_2397

fnbB

fibronectin-binding protein homologue

2.6

0.9

*SA2329

NWNM_2440

cidA

murein hydrolase regulator

3.5

1.4

  1. a Cellular main roles are in accordance with the N315 annotation of the DOGAN website [26] and/or the KEGG website [27].
  2. b Comparison of gene expression with (+) and without (-) glucose, genes with a +/- glucose ratio of ≤ 0.5 or ≥2 in the wild-type were considered to be regulated
  3. c Comparison of gene expression of wild-type (wt) and ΔccpA mutant (mut) at OD600 1 (T0) and 30 min later (T30). genes with a wt/mut ratio of ≤ 0.5 or ≥2 were considered to be regulated.
  4. * Genes containing putative cre-sites