Genomic analysis of Campylobacter fetussubspecies: identification of candidate virulence determinants and diagnostic assay targets

Table 1 C. fetus subsp. fetus (Cff) and subsp. venerealis (Cfv) virulence factors compared with 4 other Campylobacter spp.

Putative virulence type	Other spp.^a	Cff	Cfv*
Bacterial adherence	9	3^b	4^b
Motility	55–66	41	46
Two-component system genes	11–15	16	14
Toxin and resistance	15–20	9^c	7^c
Membrane proteins	185–218	209	202

Summary of C. fetus virulence gene ORFs in C. fetus subsp. fetus (Cff) and subsp. venerealis (Cfv) compared with 4 other Campylobacter spp. (adapted from Fouts et al).
^a C. jejuni, C. lari, C. upsaliensis, C. coli (Fouts et al. 2005)
^bCff – PEB1 (3) – no other adherence homologues found; Cfv ORFs – PEB1(2), cadF(0), jlpA (1-poor homology), Fibronectin binding (1), 43-kDA MOMP (0)
^c not including resistance genes for Cff and Cfv, toxin subunit ORFs only
*N.B. Cfv genome incomplete

ISSN: 1471-2180