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Table 4 Neutrality tests for the RO33 family in Dielmo, Senegal

From: Population diversity and antibody selective pressure to Plasmodium falciparum MSP1 block2 locus in an African malaria-endemic setting

      

nucleotide position

amino acid position

allele

mutation

N

197

199

200

214

270

272

290

310

66

67

72

90

91

97

104

RD0

R033

97

C

G

A

C

A

G

G

G

A

D

Q

K

G

G

D

RD1

Q72E

1

.

.

.

G

.

.

.

.

.

.

E

.

.

.

.

RD2

K90N

5

.

.

.

.

T

.

.

.

.

.

.

N

.

.

.

RD3

Q91D

4

.

.

.

.

.

A

.

.

.

.

.

.

D

.

.

RD4

G97D

2

.

.

.

.

.

.

A

.

.

.

.

.

.

D

.

RD5

G97D D104N

15

.

.

.

.

.

.

A

A

.

.

.

.

.

D

N

Year

n

h

S

Ss

(π × 10-3)

Tajima's D

(P-value)

Fu and Li's D*

(P-value)

Fu and Li's F*

(P-value)

1990

10

3

2

2

3.17

-1.4009 (>0.1)

-1.5866 (>0.1)

-1.7190 (>0.1)

1991

13

2

1

0

2.24

- 0.27429 (>0.1)

0.73235 (>0.1)

0.54307 (>0.1)

1992

10

2

2

0

7.41

1.03299 (>0.1)

1.02623 (>0.1)

1.14601 (>0.1)

1993

12

2

2

2

2.65

-1.45138 (>0.1)

-1.72038 (>0.1)

1.86451 (>0.1)

1994

13

4

4

0

8.95

-0.42367 (>0.1)

1.17832 (>0.1)

0.86962 (>0.1)

1995

12

2

1

0

2.41

-0.19492 (>0.1)

0.75202 (>0.1)

0.58317 (>0.1)

1996

18

1

0

0

0

-

-

-

1997

9

3

2

0

8.38

1.49448 (>0.1)

1.06300 (>0.1)

1.28730 (>0.1)

1998

20

2

2

0

4.26

-0.11187 (>0.1)

0.86615 (>0.1)

0.69109 (>0.1)

1999

7

2

2

0

9.07

1.64955 (>0.1)

1.17810 (>0.1)

1.37408 (>0.1)

All

124

6

5

1

4.84

-07033 (>0.1)

-0.0713 (>0.1)

-0.3316 (>0.1)

  1. Sequence diversity is shown in the upper half of the Table with the nucleotide sequence on the left and the amino acid sequence in single letter code on the right. N: number of isolates.
  2. The lower half of the Table shows the sequence diversity tests by year and all years combined (All)
  3. n: number of samples; h: number of haplotypes; S: number of segregating sites; Ss: number of singleton sites; π: average nucleotide diversity. Tajima's and Fu and Li's tests were implemented by the DnaSP version 4 software, and validated by Fisher's exact tests.
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BMC Microbiology

ISSN: 1471-2180

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