malT knockout mutation invokes a stringent type gene-expression profile in Actinobacillus pleuropneumoniae in bronchoalveolar fluid

Table 4 Nutrient-acquisition, replication and virulence genes expressed differentially* by the BALF-exposed malT mutant

Type of the product encoded by the differentially expressed gene	Up-regulated genes	Down-regulated genes
Biofilm-formation proteins	pgaA, pgaC, tadF, apfB
Toxin	apxIVA
Factors imparting resistance to antimicrobials		ostA, ccp
Peptidoglycan and LPS biosynthetic enzymes	cpxD, mrdA	dacA, murA, mltA, dacB, mreD, fbB1, kdsB, gmhA
Membrane proteins	ompP1	ompW, oapB
Amino acid transporters		brnQ, sdaC
Carbohydrate transporter	mtlA	ptsB, rbsD
Iron transport proteins	cbiO	exbD2, afuB_2, frpB, yfeC, exbB2
Protein/peptide transport proteins	dppF
Other cation transporters		ptsN
Cell division	fic
Lipid transporters	glpF
Factors involved in adaptation to unusual environment	relA
DNA transformation	comEA, comF
DNA degradation proteins	xseA
DNA replication, recombination proteins	recG, rdgC, recJ	xerC, recR, priB, polA, ligA, recA,
Protein-fate proteins	htpX, prlC	ecfE
Nucleotide metabolism enzymes	purC, purD, purT
Phopholipid and fatty acid biosynthesis and degradation enzymes	namA	accA, fabD

* Differential expression of a gene in the malT mutant is relative to the level of expression of the gene in the wild-type organism (reference sample). For complete gene names and the fold changes in gene expression see Additional file 1: Analyzed microarray data.

ISSN: 1471-2180