Figure 1From: Melanin is an essential component for the integrity of the cell wall of Aspergillus fumigatus conidiaBiosynthetic pathway of melanin in A. fumigatus. White mutants obtained by Brakhage [5] and Kwon-Chung [4] had mutations in the ALB1 (also called PKSP) gene. Steps inhibited by commercialised DHN-melanin inhibitors are localized (Tc, tricyclazole; Pq, pyroquilon; Fx, fenoxanil). 1,3,6,8-THN, 1,3,6,8-tetrahydroxynaphthalene; 1,3,8-THN, 1,3,6,8-trihydroxynaphthalene; DHN, dihydroxynaphthalene (adapted from Tsai et al. [35]).Back to article page