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Table 1 Genes of molybdenum cofactor biosynthesis in G. sulfurreducens and G. metallireducens.

From: The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens

Locus

Gene in G. sulfurreducens

Gene in G. metallireducens

Function

modE

GSU2964

Gmet_05111

regulation of molybdate-responsive genes

modD

GSU2963

none

inner membrane protein, possible quinolinate phosphoribosyltransferase

modA

GSU2962

Gmet_0512

molybdate transport (periplasmic component)

modB

GSU2961

Gmet_0513

molybdate transport (membrane component)

modC

GSU2960

Gmet_0514

molybdate transport (ATP-binding component)

moaD

none

Gmet_1044

dithiolene addition to molybdopterin (molybdopterin synthase small subunit)

moeB

none

Gmet_1043

molybdopterin synthase sulfurylase

moaE

GSU2699

none

dithiolene addition to molybdopterin (molybdopterin synthase large subunit)

moeA

GSU2703

Gmet_1038; Gmet_0336; Gmet_1804

molybdenum-sulfur ligation?

moaC

GSU2704

Gmet_1037

molybdopterin precursor Z synthesis

moaB

GSU2705

Gmet_1036

molybdopterin precursor Z synthesis

mobA

GSU3147 N-terminal domain

Gmet_0300 N-terminal domain

attachment of molybdopterin to guanosine

mobB

GSU3147 C-terminal domain

Gmet_0300 C-terminal domain

attachment of molybdopterin to guanosine

moaA

GSU3146

Gmet_0301; Gmet_0337; Gmet_2095

molybdopterin precursor Z synthesis

mosC

GSU3145

Gmet_0302; Gmet_2094

molybdenum sulfurase

pcmV

none

Gmet_2138

possible 4-hydroxybenzoyl-CoA reductase molybdenum cofactor biosynthesis protein

pcmW

none

Gmet_2139

possible 4-hydroxybenzoyl-CoA reductase molybdenum cofactor biosynthesis protein

pcmX

none

Gmet_2140

uncharacterized protein related to MobA

  1. 1Gmet_0511 is missing the N-terminal ModE domain but retains the C-terminal molybdopterin-binding MopI domains.