Table 1 Minimal fungicidal concentration (MFC) values of Candida and Aspergillus strains to AMB (amphotericin B), FLC (fluconazole), ITC (itraconazole), VRC (voriconazole) and PSC (posaconazole), determined by CLSI protocols, in the absence and presence of propofol infusion
Strains (n) | ||||||||
|---|---|---|---|---|---|---|---|---|
MFC values* range μg.ml-1 | ||||||||
Antifungals | Propofol(mg.ml-1) | C. albicans (5) | C. tropicalis (5) | C. parapsilosis (5) | C. glabrata (5) | A. fumigatus (5) | A. flavus (4) | A. niger (4) |
AMB | 0 | 0.25 | 0.25–1 | 0.06–0.125 | 0.25–0.5 | 0.25–0.5 | 0.5–1 | 0.06–0.25 |
1.25 | 0.5–1 | 1 | 2 | 2 | 1–4 | 1–>16 | 0.25–1 | |
2.5 | 0.5–2 | 1–2 | 2 | 2 | 2–4 | 1–>16 | 0.25–1 | |
5 | 2–4 | 2 | 2–8 | 4–8 | 4–16 | 4–>16 | 0.5–2 | |
FLC | 0 | 8–16 | 4–8 | 8–16 | 16 | nd | nd | nd |
1.25 | 16–>64 | >64 | >64 | >64 | nd | nd | nd | |
2.5 | 16–>64 | >64 | >64 | >64 | nd | nd | nd | |
5 | 16–>64 | >64 | >64 | >64 | nd | nd | nd | |
ITC | 0 | nd | nd | nd | nd | 0.5–16 | 0.125–0.25 | 0.125–16 |
1.25 | nd | nd | nd | nd | >16 | 2–>16 | >16 | |
2.5 | nd | nd | nd | nd | >16 | 8–>16 | >16 | |
5 | nd | nd | nd | nd | >16 | 16–>16 | >16 | |
VRC | 0 | 0.06–0.25 | 0.25–0.5 | 0.5–1 | 4–8 | 0.25–4 | 0.25–2 | 0.06–8 |
1.25 | 0.25–>2 | >2 | >2 | >8 | 2–8 | 0.25–2 | 1–16 | |
2.5 | 0.5–>2 | >2 | >2 | >8 | 2–8 | 0.5–4 | 1–16 | |
5 | 1–>2 | >2 | >2 | >8 | 2–8 | 0.5–4 | 1–16 | |
PSC | 0 | 0.06–0.125 | 0.03–0.125 | 0.06–0.125 | 1–2 | 0.03–0.25 | 0.03–0.06 | 0.06–1 |
1.25 | 1–2 | >2 | 2 | 2 | 1–4 | 0.25–2 | 0.125–8 | |
2.5 | >2 | >2 | 2 | >2 | 1–4 | 0.5–2 | 0.25–16 | |
5 | >2 | >2 | >2 | >2 | 1–4 | 0.5–4 | 0.25–>16 | |