The influence of in vitro fitness defects on pneumococcal ability to colonize and to cause invasive disease

BMC Microbiology

Table 2 Microarray analysis of the clinical isolates 14-A and 14-B with respect to genes identified in STM [6-8]. Gene annotations are given according to TIGR4 [16].

Gene	Description	Ref	14-A ST124	14-B ST555
SP 0071	immunoglobulin A1 protease	[6, 8]	-	+
SP 0143	Hypothetical protein	[8]	-	+
SP 0265	bgla; 6 phospho beta glucosidase	[6]	-	+
SP 0396	mtlf; Mannitol specific enzyme IIA component	[6]	-	+
SP 0474	pts eii; Phosphotransferase system sugar specific EII component	[6]	-	+
SP 1321	v type sodium ATP synthase subunit K	[6]	-	+
SP 1328	sodium:solute symporter family protein	[6]	-	+
SP 0268	alkaline amylopullulanase putative	[6]	+^TIGR4	+^R6
SP 0629	conserved hypothetical protein	[7]	+^TIGR4	+^R6
SP 0933	pyrroline 5 carboxylate reductase	[7]	+^TIGR4	+^R6
SP 1018	tdk; Thymidine kinase	[6]	+^TIGR4	+^R6
SP 1029	RNA methyltransferase TrmA family	[6]	+^TIGR4	+^R6
SP 1343	ptrb; Protease II (oligopeptidase B)	[6]	+	-
SP 1344	Conserved hypothetical protein	[6]	+	-
SP 1433	Hypothetical protein	[6]	+	-
SP 1434	ABC transporter ATP binding/permease protein	[6]	+	-
SP 2095	Conserved hypothetical protein	[6]	+	-
SP 2164	pts eii; Phosphotransferase system sugar specific EII component	[6]	+	-

Note: Genes that are present are designated +, genes that are absent are designated -. In cases where sequence differences were found between the test isolates, subscripts indicate which reference strain the test strain hybridized to.

ISSN: 1471-2180