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Table 2 The most significant (P < 0.05) differentially expressed genes of S. mutans in 200 μm vs. 100 μm biofilms

From: DNA-microarrays identification of Streptococcus mutans genes associated with biofilm thickness

Locus numbera

Descriptiona

Mb

P valuec

Bd

SMU.574c

putative membrane protein

1.169

0.006

4.950

SMU.1782

conserved hypothetical protein

1.250

0.016

2.504

SMU.744

putative cell division protein FtsY signal recognition

1.236

0.016

2.545

SMU.1889c

hypothetical protein

0.850

0.016

2.536

SMU.1537

putative glycogen biosynthesis protein GlgD

0.598

0.016

2.395

SMU.1488c

conserved hypothetical protein

1.103

0.018

2.187

SMU.402

pyruvate formate-lyase

0.788

0.019

1.814

SMU.943c

putative hydroxymethylglutaryl-CoA synthase

-0.617

0.019

1.780

SMU.495

glycerol dehydrogenase

0.572

0.020

1.596

SMU.804

hypothetical protein

0.940

0.025

1.234

SMU.1578

putative biotin operon repressor

0.532

0.025

0.993

SMU.814

putative MutT-like protein

0.598

0.025

0.984

SMU.618

hypothetical protein

1.442

0.025

0.912

SMU.987

cell wall-associated protein precursor WapA

1.020

0.025

0.881

SMU.417

conserved hypothetical protein

-0.622

0.025

0.866

SMU.929c

conserved hypothetical protein

-0.562

0.028

0.776

SMU.125

conserved hypothetical protein

0.457

0.032

0.518

SMU.1841

putative PTS system, sucrose-specific IIABC component

0.782

0.038

0.300

SMU.609

putative 40K cell wall protein precursor

0.454

0.042

0.144

SMU.1626

50S ribosomal protein L1

0.897

0.042

0.401

SMU.1298

50S ribosomal protein L31

-0.692

0.042

0.081

SMU.630

hypothetical protein

-0.483

0.042

0.036

SMU.892

putative type I restriction-modification system, specificity determinant

-0.745

0.043

0.067

SMU.2105

hypothetical protein

0.862

0.043

-0.127

SMU.2146c

hypothetical protein

0.993

0.043

-0.146

SMU.1975c

conserved hypothetical protein possible membrane protein

0.900

0.043

0.182

SMU.102

putative PTS system, IID component

-0.422

0.045

-0.218

SMU.149

putative transposase

0.795

0.046

-0.285

SMU.883

dextran glucosidase DexB

0.393

0.046

-0.322

SMU.99

fructose-1,6-biphosphate aldolase

0.510

0.046

-0.331

SMU.27

putative acyl carrier protein AcpP

0.809

0.047

-0.059

SMU.91

peptidyl-prolyl isomerase RopA (trigger factor)

0.544

0.049

-0.525

SMU.1421

putative dihydrolipoamide acetyltransferase, E2 component

0.565

0.049

-0.564

SMU.886

galactokinase, GalK

0.676

0.049

-0.577

SMU.753

conserved hypothetical protein

-0.700

0.049

-0.592

SMU.442

conserved hypothetical protein

0.435

0.049

-0.600

SMU.1854

conserved hypothetical protein

-0.748

0.049

-0.229

SMU.940c

putative hemolysin III

-0.651

0.049

-0.473

  1. aBased on the genome annotation of S. mutans provided by TIGR.
  2. bLog2-fold expression according to the M value, M > 0 means upregulation and M < 0 downregulation of the gene.
  3. cModerated t-test and its corresponding P value, adjusted by Benjamini and Yekutiely method.
  4. dBayesian test value, meaning the probability for a gene to be differentially expressed. Genes are listed according to their decreasing statistical importance according to their B-value.