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Table 1 The most significant (P ≤ 0.05) differentially expressed genes of S. mutans in 400 μm vs. 100 μm biofilms

From: DNA-microarrays identification of Streptococcus mutans genes associated with biofilm thickness

Locus numbera

Descriptiona

Mb

P valuec

Bd

SMU.173

putative ppGpp-regulated growth inhibitor

1.021

0.001

5.781

SMU.1710c

conserved hypothetical protein

1.246

0.001

5.520

SMU.991

putative ribonucleotide reductase

0.932

0.004

4.187

SMU.1080c

conserved hypothetical protein possible transposon-related protein

-0.635

0.013

2.948

SMU.564

conserved hypothetical protein

0.666

0.018

2.409

SMU.1974

putative pyrroline carboxylate reductase

0.696

0.018

2.267

SMU.1758c

conserved hypothetical protein

-0.666

0.028

1.676

SMU.125

conserved hypothetical protein

0.914

0.028

1.564

SMU.359

translation elongation factor G (EF-G)

0.978

0.028

1.477

SMU.59

adenylosuccinate lyase

0.691

0.028

1.381

SMU.987

cell wall-associated protein precursor WapA

0.760

0.028

1.313

SMU.85

putative phosphomethylpyrimidine kinase

0.623

0.032

1.101

SMU.2146c

hypothetical protein

0.656

0.036

0.963

SMU.37

phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

0.540

0.036

0.786

SMU.02

putative DNA polymerase III, beta subunit

0.605

0.036

0.775

SMU.609

putative 40K cell wall protein precursor

0.739

0.04

0.575

SMU.574c

putative membrane protein

0.814

0.04

0.487

SMU.1353

putative transposase

0.461

0.04

0.485

SMU.1839

mannose-6-phosphate isomerase

0.590

0.041

0.471

SMU.641

putative oxidoreductase

-0.595

0.044

0.225

SMU.1889c

hypothetical protein

0.860

0.044

0.213

SMU.442

conserved hypothetical protein

1.416

0.044

0.171

SMU.1646c

conserved hypothetical protein, possible hemolysis inducing protein

1.031

0.044

0.157

SMU.229

conserved hypothetical protein

-0.480

0.045

0.096

SMU.1760c

conserved hypothetical protein

-0.548

0.047

0.016

SMU.84

putative tRNA pseudouridine synthase A

0.715

0.048

-0.056

SMU.2005

putative adenylate kinase

-0.577

0.05

-0.147

SMU.1488c

conserved hypothetical protein

0.725

0.05

0.033

SMU.1642c

conserved hypothetical protein

0.771

0.05

-0.196

  1. aBased on the genome annotation of S. mutans provided by TIGR.
  2. bLog2-fold expression according to the M value, M > 0 means upregulation and M < 0 downregulation of the gene.
  3. cModerated t-test and its corresponding P value, adjusted by Benjamini and Yekutiely method.
  4. dBayesian test value, meaning the probability for a gene to be differentially expressed. Genes are listed according to their decreasing statistical importance according to their B-value.