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Table 2 Top paths in the MAP-RES network

From: Mycobacterium tuberculosis interactome analysis unravels potential pathways to drug resistance

Path

Score

SOS

 

Rv0242c (FabG4) -(276)→Rv2245 (KasA) -(596)→Rv2737c (RecA)

0.0102

Rv0242c -(276)→Rv2245 -(596)→Rv2737c -(44)→Rv2720 (LexA)

0.0727

Rv0904c (AccD3) -(241)→Rv1547 (DnaE1)

0.1000

Rv0824c (DesA1) -(162)→Rv0823c -(247)→Rv2737c

0.1344

Rv0242c -(276)→Rv2245 -(596)→Rv2737c -(96)→Rv2593c (RuvA)

0.1352

Rv2246 (KasB) -(400)→Rv1131 (GltA1) -(526)→Rv1629 (PolA)

0.1389

CYTOCHROMES

 

Rv2243 (FabD) -(200)→Rv3546 (FadA5) -(395)→Rv3545c (Cyp125)

0.0174

Rv0242c -(436)→Rv2243 -(200)→Rv3546 -(395)→Rv3545c

0.0203

Rv1350 (FabG2) -(205)→Rv2243 -(200)→Rv3546 -(395)→Rv3545c

0.0230

Rv1483 (FabG1) -(121)→Rv2243 -(200)→Rv3546 -(395)→Rv3545c

0.0352

Rv2243 -(257)→Rv0769 -(558)→Rv0766c (Cyp123)

0.0643

Rv0242c -(436)→Rv2243 -(559)→Rv2782c (PepR) -(513)→Rv1622c (CydB)

0.0655

Rv0242c -(436)→Rv2243 -(257)→Rv0769 -(558)→Rv0766c (Cyp123)

0.0673

Rv0242c -(436)→Rv2243 -(559)→Rv2782c -(578)→Rv2193 (CtaE)

0.0738

Rv0643c (MmaA3) -(350)→Rv0892 -(350)→Rv0568 (Cyp135B1)

0.0956

Rv0643c -(350)→Rv0892 -(350)→Rv3059 (Cyp136)

0.0956

ANTIBIOTIC EFFLUX PUMPS

 

Rv2245 -(565)→Rv0340 -(447)→Rv0342 (IniA)

0.0526

Rv0242c -(276)→Rv2245 -(565)→Rv0340 -(447)→Rv0342

0.0580

Rv2243 -(356)→Rv2238c (AhpE) -(569)→Rv2687c

0.0901

Rv2243 -(2)→Rv2245 -(565)→Rv0340 -(447)→Rv0342

0.1151

Rv0642c (MmaA4) -(350)→Rv3248c (sahH) -(486)→Rv3240c -(323)→Rv3239c

0.1365

Rv0642c -(350)→Rv3248c -(350)→Rv1988

0.1385

Rv1350 -(90)→Rv2245 -(596)→Rv2737c -(429)→Rv2882c (Frr) -(584)→Rv0783c (EmrB)

0.3169

Rv2245 -(369)→Rv1908c (KatG) -(350)→Rv1988

0.3833

Rv0242c -(276)→Rv2245 -(369)→Rv1908c -(350)→Rv1988

0.3888

HORIZONTAL GENE TRANSFER

 

Rv0644c (MmaA2) -(350)→Rv3248c -(486)→Rv3240c (SecA1)

0.0812

Rv2243 -(202)→Rv2925c (Rnc) -(378)→Rv3659c

0.0913

Rv2243 -(202)→Rv2925c -(378)→Rv3659c -(63)→Rv3660c

0.1538

Rv2245 -(596)→Rv2737c -(514)→Rv2890c (RpsB) -(187)→Rv3240c

0.3715

Rv2524c (Fas) -(464)→Rv2918c (GlnD) -(380)→Rv2890c -(187)→Rv3240c

0.4833

  1. The weighted score for each path is shown. The nodes upregulated by MAP drugs are indicated in bold typeface, while those that are upregulated by other drugs are underlined. The figures in parentheses indicate the edge weight; a lower edge weight indicates a higher confidence in the interaction. The edge weights range from 1 to 999. Lower edge weights are better. STRING scores range from 1 to 999. However, since edge weights are conventionally represented such that lower weights indicate better paths, the edge weights have been computed as 1000-STRING_score.