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Table 3 Bifidobacterium group and species of faeces and duodenal biopsies from children quantified by qPCR.

From: Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease

Microbial group in biopsy samples

Bacterial countsa (Log cells/g)

P-value Mann-Whitney/Test Bonferroni adjustment

 

Active CD (n = 25)

Non-active CD (n = 8)

Control (n = 8)

Active- non-active CD

Control- active CD

Control- non-active CD

 

Median

IQR

Median

IQR

Median

IQR

   

Bifidobacterium group

5.95

5.55–6.21

6.15

4.97–6.28

6.27

6.03–6.80

0.604

0.009*, i

0.461

B. longum

4.66

4.36–5.37

4.95

4.90–5.60

5.60

5.33–5.73

0.310

0.004*, i

0.368

B. breve

5.14

4.59–5.46

3.05

3.02–3.50

5.21

5.00–5.80

0.020*

0.630

0.100

B. bifidum

4.35

3.40–4.75

3.98

2.15–4.44

4.17

3.48–4.66

0.800

0.700

0.950

B. adolescentis

3.22

2.86–3.74

3.06

-

3.87

1.80–3.30

0.600

0.327

0.667

B. catenulatum group

4.08

3.16–4.60

4.12

4.04–4.53

4.10

3.76–4.46

0.736

0.757

0.660

B. angulatum

2.95

1.54–3.80

4.10

-

3.55

1.58–4.44

0.275

0.933

0.900

B. lactis

6.33

5.50–6.18

-

-

5.28

4.59–5.70

-

0.033*

-

B. longum subsp. infantis

-

-

-

-

-

-

-

-

-

B. dentium

4.23

3.45–5.23

4.00

-

-

-

0.627

-

-

Microbial group in faecal samples

Bacterial countsa (Log cells/g)

P-value Mann-Whitney test Bonferroni adjustment

 

Active CD (n = 30)

Non-active CD (n = 18)

Control (n = 30)

Active- non-active CD

Control- active CD

Control- non-active CD

 

Median

IQR

Median

IQR

Median

IQR

   

Bifidobacterium group

9.67

8.68–9.90

8.77

8.58–9.60

9.80

9.23–10.33

0.183

0.014*, i

0.002*, i

B. longum

8.90

8.56–9.40

8.30

7.78–9.00

9.28

8.88–10.10

0.030*

0.038*

< 0.001*, i

B. breve

6.97

5.56–7.82

4.02

3.08–5.15

6.94

6.18–8.02

< 0.001*, i

0.860

< 0.001*, i

B. bifidum

7.64

6.42–8.16

6.74

6.40–6.87

6.96

6.67–7.93

0.030*

0.577

0.050*

B. adolescentis

6.95

5.55–7.92

5.40

4.93–7.76

5.97

5.37–6.60

0.112

0.050*

0.633

B. catenulatum group

7.16

6.50–8.68

7.84

7.07–8.50

7.65

7.56–8.42

0.425

0.106

0.758

B. angulatum

4.96

4.64–7.20

4.68

4.24–5.07

4.65

4.12–5.00

0.548

0.153

0.569

B. lactis

7.12

5.30–7.45

5.17

4.66–7.20

5.45

4.66–7.07

0.175

0.081

0.780

B. longum subsp. infantis

6.57

5.80–7.76

7.47

6.83–7.82

6.68

6.45–7.06

0.192

0.341

0.117

B. dentium

6.28

6.10–6.30

5.24

4.66–5.82

5.20

3.86–5.30

0.111

0.133

0.571

  1. a Data are shown as medians and interquartile range (IQR) of cell number per gram of faecal or duodenal biopsy sample.
  2. * Statistical differences were calculated by using Mann-Whitney U test comparing two variables. Significantly difference between groups was considered at P < 0.050.
  3. i Statistical differences were corrected for a multiple comparison test (3 variable) by using Bonferroni adjustment. Significantly difference between groups was considered at P < 0.017.
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BMC Microbiology

ISSN: 1471-2180

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