Lack of genomic evidence of AI-2 receptors suggests a non-quorum sensing role for luxS in most bacteria

BMC Microbiology

Table 1 A literature survey of the relationship between the presence of the luxS gene and QS-2 dependent behavior in bacterial species carrying either a luxP- or a lsrB-gene homolog in their genome

	Talk^a	Listen^a		Answer^b
Strain	*luxS*	*luxP*	*lsrB*	AI-2 related phenotype	Chemical compl.^c	References
Actinobacillus actinomycetemcomitans	+	-	+	yes	+/SN	[45]
				yes	nd	[70]
				yes	+/AI-2	[68]
				yes	+/AI-2	[25, 52]
Bacillus anthracis	+	-	+	yes	nd	[71]
Bacillus cereus	+	-	+	yes	+/AI-2	[72]
Bacillus thuringensis	+	-	+	nd	nd	-
Desulfovibrio desulfuricans	-	(+)	-	nd	nd	This work
Escherichia coli	+	-	+	yes	+/SN	[73]
				yes	+/SN	[30]
				yes	+/SN	[21]
				Q	nd	[74]
Haemophilus somnus	+	-	+	H	nd	[75]
Klebsiella pneumoniae	+	-	+	H	nd	[76]
Pasteurella multocida	+	-	+	H	nd	[77]
Photorhabdus luminescens	+	-	+	yes	nd	[56]
				yes	+/AI-2	[78]
Rhodobacter capsulatus	-	-	+	nd	nd	This work
Rhodobacter sphaeroides 2.4.1	-	-	+	nd	nd	This work
Salmonella enterica	+	-	+	yes	nd	[79]
Salmonella typhimurium	+	-	+	yes	+/AI-2	[20]
				yes	+/AI-2	[22]
Marinomonas sp. MED121	-	(+)	-	nd	nd	This work
Neptuniibacter caesariensis	-	(+)	-	nd	nd	This work
Sinorhizobium meliloti	-	-	+	nd	nd	This work
Shigella dysenteriae	+	-	+	nd	nd	-
Shigella flexneri	+	-	+	yes	+/SN	[80]
Vibrio anguillarum	+	+	-	yes	nd	[81]
Vibrio cholerae	+	+	-	yes	+/SN	[82]
Vibrio harveyi	+	+	-	yes	+/SN	[83]
Vibrio fischeri	+	+	-	yes	+/SN	[84]
Vibrio parahaemolyticus	+	+	-	yes	+/SN	[85]
Vibrio vulnificus	+	+	-	yes	+/SN	[38]
Yersinia pestis	+	-	+	nd	nd	[86]
				nd	nd	[87]

A more detailed description of the findings of the papers cited herein is available as additional file 1 (Table 1s).
^a +: positive (>50% protein identity); (+): positive (<50% protein identity); -: negative (<30% protein identity);
^b H: hypothesized; nd: not determined; Q: questioned;
^c +: successful complementation; -: unsuccessful complementation; nd: not determined; AI-2: complementation with pure autoinducer; DPD: complementation with precursor; SN: complementation with co-culture or conditioned supernatants of luxS-positive strain.

ISSN: 1471-2180