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Table 2 In vitro antifungal susceptibility of all oral yeast isolates (n = 296)

From: Species distribution and in vitro antifungal susceptibility of oral yeast isolates from Tanzanian HIV-infected patients with primary and recurrent oropharyngeal candidiasis

Species/Antifungal agent

MIC (μ/ml)

%R*

 

MIC Range

MIC50

MIC90

GM

 

C. albicans (250)

     

Amphotericin B

0.125 – 1

0.5

0.5

0.326

 

Nystatin

2 – >16

4

4

3.377

 

Fluconazole

0.063 – 32

0.25

2

0.330

0

Itraconazole

0.016 – >16

0.016

0.063

0.021

4

Miconazole

0.016 – 4

0.016

0.063

0.025

 

Clotrimazole

0.125 – 2

1

2

0.474

 

C. glabrata (20)

     

Amphotericin B

0.5 – 1

0.5

1

0.545

 

Nystatin

2 – 4

4

4

3.668

 

Fluconazole

2 – 64

16

32

13.22

5

Itraconazole

0.016 – 4

1

4

0.615

55

Miconazole

0.063 – 0.5

0.25

0.5

0.189

 

Clotrimazole

0.125 – 2

1

2

0.474

 

C. krusei (10)

     

Amphotericin B

0.5 – 1

1

1

0.683

 

Nystatin

2 – 8

4

4

0.965

 

Fluconazole

64 – >64

64

>64

76.1

100

Itraconazole

0.031 – 0.5

0.125

0.5

0.134

0

Miconazole

1 – 2

2

2

1.464

 

Clotrimazole

0.063 – 0.25

0.125

0.125

0.116

 

C. tropicalis (8)

     

Amphotericin B

0.25 – 1

0.5

-

0.458

 

Nystatin

2 – 4

4

-

3.084

 

Fluconazole

1 – >64

16

-

14.67

50

Itraconazole

0.016 – 2

0.5

-

0.176

37.5

Miconazole

0.125 – 4

2

-

0.840

 

Clotrimazole

0.031 – 4

2

-

0.337

 

C. kefyr (3)

     

Amphotericin B

0.5 – 0.5

0.5

-

0.5

 

Nystatin

2 – 4

2

-

2.244

 

Fluconazole

0.25 – 0.5

0.5

-

0.396

0

Itraconazole

0.016 – 0.031

0.031

-

0.019

0

Miconazole

0.016 – 0.016

0.016

-

0.016

 

Clotrimazole

0.016 – 0.016

0.016

-

0.016

 

C. pintolopesii (1)

     

Amphotericin B

0.5

-

-

-

 

Nystatin

4

-

-

-

 

Fluconazole

16

-

-

-

0

Itraconazole

1

-

-

-

100

Miconazole

0.25

-

-

-

-

Clotrimazole

1

-

-

-

-

C. dubliniensis (1)

     

Amphotericin B

0.25

-

-

-

 

Nystatin

4

-

-

-

 

Fluconazole

0.5

-

-

-

0

Itraconazole

0.016

-

-

-

0

Miconazole

0.016

-

-

-

 

Clotrimazole

0.016

-

-

-

 

S. cerevisiae (3)

     

Amphotericin B

0.5 – 1

0.5

-

0.445

 

Nystatin

2 – 4

4

-

2.828

 

Fluconazole

8 – 8

8

-

8

0

Itraconazole

0.25 – 0.5

0.25

-

0.353

0

Miconazole

0.063 – 0.25

0.063

-

0.088

 

Clotrimazole

0.063 – 1

0.063

-

0.099

 

All isolates (296)

     

Amphotericin B

0.125 – 1

0.5

0.5

0.352

 

Nystatin

2 – >16

4

4

3.39

 

Fluconazole

0.063 – >64

0.5

16

0.592

5

Itraconazole

0.016 – >16

0.016

0.5

0.031

8.4

Miconazole

0.016 – 4

0.031

1

0.036

 

Clotrimazole

0.016 – 4

0.016

1

0.029

 
  1. MIC50 – MIC value able to inhibit 50% of the isolates tested.
  2. MIC90 – MIC value able to inhibit 90% of the sample tested.
  3. GM – Geometric Mean.
  4. R* – Percent resistance using interpretive breakpoint criteria of the CLSI (2002): Itraconazole resistance ≥ 1; Fluconazole resistance ≥ 64 μg/ml.
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BMC Microbiology

ISSN: 1471-2180

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