Comparative gene expression profiling in two congenic mouse strains following Bordetella pertussis infection

BMC Microbiology

Table 2 Candidate susceptibility genes

Symbol	Max.fold^a	P- value	Group^b	Description
2610204M08Rik	1.5	0.0000000	A	RIKEN cDNA 2610204M08 gene
BC022687	3.7	0.0005453		cDNA sequence BC022687
LOC544906^c	2.6	0.0024627		similar to monoclonal antibody heavy chain
LOC382694^c	2.8	0.0043821		similar to immunoglobulin heavy chain
LOC211331^c	2.7	0.0002482		similar to Ig H-chain
LOC238440^c	2.7	0.0016035		similar to IgE antibody heavy chain (VDJ)
LOC238448^c	3.2	0.0000868		similar to Igh-VJ558 protein
LOC544911^c	2.1	0.0000310		similar to heavy chain V region VH558 A1/A4 precursor
LOC432692	1.4	0.0005147	B	LOC432692
LOC544805^c	3.5	0.0000050		similar to Ig heavy chain variable region precursor
1700001K19Rik	1.6	0.0002085		RIKEN cDNA 1700001K19 gene
Amn	1.7	0.0002930		amnionless
Ppp1r13b	2.2	0.0000019		protein phosphatase 1, regulatory (inhibitor) subunit 13B
Adssl1	1.5	0.0001518		adenylosuccinate synthetase like 1
Akt1	1.8	0.0000206		thymoma viral proto-oncogene 1
AI450948	1.5	0.0048316		expressed sequence AI450948
Igh-1a^c,d	3.6	0.0000000		immunoglobulin heavy chain 1a (serum IgG2a)

^aMaximum fold-change between genes that are located in Bps1 and that are significantly differentially expressed between C3H and HcB-28 mice.
^bHierarchical clustering as presented in figure 2, higher in C3H (A) or higher in HcB-28 (B).
^cIn the most recent annotation of the murine genome, eight probes map to the Immunoglobulin heavy chain complex (Igh) similar to Ig heavy chain variable region precursor.
^dThe oligo was designed based on accession number XM_484178 annotated as Igh-1a. Because this annotation is based on the reference C57BL/6 mice, the oligo can be considered as Igh-1b annotated.

ISSN: 1471-2180