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Figure 3 | BMC Microbiology

Figure 3

From: Assessing the reliability of eBURST using simulated populations with known ancestry

Figure 3

Performance of eBURST for a population simulated in the absence of recombination. All 1000 isolates from an equilibrium population, simulated with θ = 10 and ρ = 0, were displayed as A) the true ancestry groups that eBURST attempts to recover and B) eBURST groups. True ancestor-descendant relationships are shown in (A) by lines between the nodes and continuously connected groups of STs define the ancestry groups. The eBURST population snapshot (B) shows the clonal complexes and singletons. The largest eBURST group (Group 1) is labelled. C) Group 1 shows all of the additional SLVs (pink lines) overlaid on the eBURST diagram. D) Complete ancestry of the STs within eBURST Group 1 showing intermediate extinct STs (yellow squares). The isolates descending from the two extinct STs on the left (arrows) are in separate ancestry groups although they are in the same eBURST group (see text and supplementary online information). In A) node size is proportional to the frequency of an ST in the sample, and nodes are coloured by eBURST group. Nodes shaped as hexagons indicate the founders predicted by eBURST; diamonds are sampled STs; yellow squares are extinct ancestors of STs in the population; white triangles are singletons. In eBURST groups, the circles indicate STs and the area of each circle denotes the frequency of the ST. Blue circles denote the predicted founders of eBURST groups, yellow denotes a subgroup founder [11]. Black lines between STs show the inferred evolutionary relationships from the founder to the other STs in the eBURST group. Further description of Figure 3 is available as additional files.

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