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Table 2 S protein amino acid replacements and lamivudine-resistant rt domain polymerase mutations found in blood donors.

From: Hepatitis B virus genotypes circulating in Brazil: molecular characterization of genotype F isolates

Sample

Genotype

Serotype

Determinant a replacements

Lamivudine resistance mutation (P gene)*

358-S

A

adw2

Y100C

-

312-SE

A

adw2

Y100C

-

161-CW

A

adw2

Y100C

-

043-N

A

adw2

-

rtV173L, rtL180M, rtM204V

020-N

D

ayw3

T118V, A128V

-

328-S

D

ayw3

T118V, A128V

-

344-S

D

ayw3

T118V, A128V

-

209-CW

F

adw4

-

rtL180M, rtM204I

052-N

F

adw?

L127I

-

  1. *Deduced amino acid sequence of HBV polymerase based on the shifted reading frame of the sequenced S gene (P gene: aa rt 9–236).