Figure 10From: Effects of disrupting the polyketide synthase gene WdPKS1 in Wangiella [Exophiala] dermatitidis on melanin production and resistance to killing by antifungal compounds, enzymatic degradation, and extremes in temperatureSurvival of W. dermatitidis yeast cells in the presence of lysing enzymes. Strain 8656, wdpks1 Δ-1, and wdpks1 Δ-1-501 yeast cells grown for 7 days in YPD medium at 37°C and incubated in different concentration of Sigma lysing enzymes. Survival was compared to fungal cells incubated in PBS. The melanin-deficient mutant was significantly more susceptible to killing by incubation in lysing enzymes. Values are of the standard errors of the means for three measurements. *, p < 0.001 and **, p < 0.01. The experiment was repeated with similar results.Back to article page