Enzyme name | Potential Inhibitor | Prior testing? | Reference |
---|---|---|---|
acetyl-CoA carboxylase | pseudopeptide pyrrolidine dione antibiotics | SA, B | [45] |
4-amino-4-deoxychorismate synthase | (6s)-6-fluoroshikimate | B | [46] |
Adenosylmethionine decarboxylase | CGP 40215A, AdoMao | B | |
asparagine synthase (glutamine-hydrolysing) | mucochloric and mucobromic acids, L-cysteine sulfinic acid | B | |
dihydrofolate reductase | methylpteridines | B | [51] |
dihydropteroate synthase | Sulfone and sulfanilamide sulfa drugs | B | |
3-dehydroquinate synthase | carbocyclic inhibitors | B | [54] |
FMN adenylyltransferase (FAD synthase) | Riboflavin 5'-pyrophosphate | F | [55] |
glycerol-3-phosphate dehydrogenase (NADP) | 5-n-alk(en)ylresorcinols | NF | [56] |
glutamine synthetase | L-methionine sulfoximine, aminomethylene-bisphosphonic acid derivatives | NF | |
glutamyl-tRNA reductase | see table I in paper | NF | [59] |
GTP cyclohydrolase I | Diamino-6-hydroxypyrimidine, pterins | NF | |
Hydroxymethylglutaryl CoA reductase (ir) | statins | NF | |
Hydroxymethylglutaryl CoA synthase (ir) | beta-lactone, 3-Hydroxy-3-methylglutaryldithio-coenzyme A | NF | |
isopentenyl-diphosphate D-isomerase | NE21650 | NF | [66] |
methionine adenosyltransferase | adduncts 14 and 16 | B | [67] |
Phosphatidate phosphatase | Propranolol | NF | [68] |
phosphoribosylpyrophosphate synthetase | MRPP, ARPP | NF | [69] |
riboflavin synthase | 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones | B | [70] |
spermidine synthase | adenosylspermidine, dicyclohexylamine | SA, B | |
thiamine transport via ABC system | azidobenzoyl derivatives of thiamin, methylene blue | F | |
thioredoxin reductase | Arsenicals, Aurothioglucose | NF | |
UDP-N-acetylglucosamine 4-epimerase | uridine analogs | NF | [77] |
UDP-N-acetylenolpyruvoylglucosamine reductase | 4-thiazolidinones | B | [78] |