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Table 1 The inhibition of methionine adenosyltransferase by methionine analogues. The M. smegmatis enzyme was incubated with 1 mM methionine, 10 mM ATP, 20 mM Mg2+, 150 mM K+, and 10 mM inhibitor, as described in the Methods section.

From: Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis

Inhibitor

Inhibition (%)

Inhibitor

Inhibition (%)

α-Methyl-DL-methionine

18.8 ± 3.7

3-Methylthio propionaldehyde

18.4 ± 3.7

L-Methionine sulfoxide

4.0 ± 0.8

L-Methionine methyl ester

17.7 ± 3.5

L-Methionine sulfone

9.2 ± 1.8

L-Penicillamine

15.0 ± 3.0

Cycloleucine

25.8 ± 5.1

L-Methionine sulfoximine

12.6 ± 2.5

L-Ethionine

20.4 ± 4.1

(R)-Methioninol

0.0 ± 0.0

L-Methioninamide

23.9 ± 4.8

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