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Table 1 Susceptibility pattern of tested A. fumigatus isolates to Prochloraz and clinical azoles

From: Development of cross-resistance by Aspergillus fumigatus to clinical azoles following exposure to prochloraz, an agricultural azole

A. fumigatus isolate

Time of exposure (days)

 

MIC (mg/L)

PCZ

VRC

POS

ITZ

FLC

LMF05

0

0.125

0.125

0.25

2

>64

10

0.25

0.25

0.5

2

>64

20

8

2

1

4

>64

30

32

8

2

8

>64

 

Ø30

32

2

2

2

>64

LMF11

0

0.125

0.25

0.125

0.5

>64

10

0.125

2

0.25

1

>64

20

8

8

1

2

>64

30

32

>16

4

4

>64

 

Ø30

32

2

1

0.5

>64

LMN60

0

0.25

0.25

0.125

0.25

>64

10

4

8

0.25

1

>64

20

8

8

0.5

2

>64

30

64

>16

4

4

>64

 

Ø30

64

2

1

0.25

>64

  1. PCZ, Prochloraz; VRC, Voriconazole; POS, Posaconazole; ITZ, Itraconazole; FLC, Fluconazole; Ø, MIC after 30 days of culture in the absence of PCZ.