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Figure 2 | BMC Microbiology

Figure 2

From: Zinc protects against shiga-toxigenic Escherichia coli by acting on host tissues as well as on bacteria

Figure 2

Effect of hypoxanthine plus xanthine oxidase on barrier function and Stx2 translocation in T84 cells. Panels A-C show effects on TER, while Panel D shows effect on Stx2 translocation. The “standard” concentration of hypoxanthine was 400 μM if not otherwise stated, and the standard concentration of XO was 1 U/mL. Panel A, effect of various concentrations of hypoxanthine on TER. The “zero” hypoxanthine condition received 1% DMSO vehicle alone. Panel B, additive effect of zinc with butyrate on TER. Panel C, protection by zinc against the drop in TER induced by hypoxanthine plus XO. Panel D, protection by zinc against Stx2 translocation triggered by hypoxanthine plus xanthine oxidase.

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