Table 1 Overview of the clinical data (bodyweight decrease, relative lung weight, lung damage) and virological parameters (virus titers) partly adapted from Van den Brand et al. 2012 Plos One[21]
From: Activation of coagulation and tissue fibrin deposition in experimental influenza in ferrets
Day | Â | 1 | 2 | 3 | 4 | 7 | 14 |
|---|---|---|---|---|---|---|---|
Bodyweight | H3N2 | -51 | -100 | -69 | -124 | -186 | -205 |
(16–86) | (9–190) | (33–104) | (117–130) | (141–231) | (101–309) | ||
pH1N1 | -68 | -169 | -142 | -250 | -251 | -193 | |
(22–114) | (161–176) | (74–210) | (185–315) | (190–312) | (19–368) | ||
H5N1 | -70 | -131 | -170 | -190 | ┼ | ┼ | |
(35–105) | (112–149) | (142–198) | (135–246) |  |  | ||
Control | -44 | -20 | +7 | -34 | -62 | -46 | |
(31–57) | (+30 - -69) | (+40- -25) | (+19 - -88) | (+10 - -134) | (+30 – 123) | ||
Relative lung weight 10-2 gram | H3N2 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 |
(0.5-0.7) | (0.6-0.7) | (0.5-0.6) | (0.5-0.7) | (0.6-0.7) | (0.5-0.6) | ||
pH1N1 | 0.8 | 1.0 | 1.1 | 1.2 | 1.3 | 0.7 | |
(0.7-0.8) | (0.9-1.2) | (0.9-1.2) | (1.1-1.3) | (1.0-1.6) | (0.6-0.8) | ||
H5N1 | 0.9 | 1.4 | 1.7 | 2.4 | ┼ | ┼ | |
(0.6-1.2) | (1.1-1.7) | (1.2-2.2) | (2.0-2.7) | Â | Â | ||
Control | 0.7 | 0.7 | 0.6 | 0.6 | 0.6 | 0.6 | |
(0.7-0.8) | (0.6-0.8) | (0.6-0.6) | (0.6-0.7) | (0.6-0.7) | (0.5-0.7) | ||
Lung damage % | H3N2 | 3.8 | 2.5 | 0 | 0 | 0 | 1.3 |
(0–8.5) | (0–5.4) |  |  |  | (0–3.8) | ||
| Â | pH1N1 | 22.5 | 25.0 | 40.0 | 45.0 | 47.5 | 25.0 |
| Â | (17.5-27.5) | (19.2-30.8) | (31.8-48.1) | (35.0-55.0) | (30.4-64.6) | (19.2-30.8) | |
H5N1 | 25.0 | 55.0 | 62.5 | 77.5 | ┼ | ┼ | |
(12.1-37.9) | (35.9-74.2) | (40.3-84.7) | (55.3-99.7) | Â | Â | ||
Control | 3.8 | 6.3 | 6.3 | 1.3 | 5.0 | 3.8 | |
(1.3-6.3) | (1.5-11) | (1.5-11) | (0–3.8) | (5–5) | (1.3-6.3) | ||
Turbinates/nasal concha log TCID50 | H3N2 | 7.0 | 6.3 | 5.1 | 4.8 | neg | neg |
(5.5-8.5) | (5.4-7.3) | (3.9-6.2) | (3.4-6.1) | Â | Â | ||
pH1N1 | 8.2 | 8.0 | 7.6 | 7.0 | neg | neg | |
(8.0-8.5) | (7.7-8.3) | (7.0-8.2) | (6.2-7.9) | Â | Â | ||
H5N1 | 4.8 | 5.0 | 5.6 | 4.9 | ┼ | ┼ | |
(3.5-6.1) | (4.4-5.6) | (4.1-7.0) | (3.4-6.4) | Â | Â | ||
Trachea log TCID50 | H3N2 | 2.4 | neg | neg | neg | neg | neg |
(<1.7-3.1) | Â | Â | Â | Â | Â | ||
pH1N1 | 5.5 | 5.4 | 5.9 | 5.5 | neg | neg | |
(5.0-6.0) | (5.0-5.9) | (5.6-6.3) | (4.3-6.9) | Â | Â | ||
H5N1 | 5.5 | 4.7 | 5.1 | 4.7 | ┼ | ┼ | |
(4.7-6.3) | (4.2-5.1) | (4.1-6.2) | (3.4-6.0) | Â | Â | ||
Lung log TCID50 | H3N2 | neg | Neg | Neg | neg | neg | neg |
pH1N1 | 7.5 | 5.2 | 5.5 | 5.6 | neg | Neg | |
(7.2-7.8) | (4.7-5.8) | (5.1-6.0) | (5.1-6.2) | Â | Â | ||
|  | H5N1 | 6.6 (6.0-7.2) | 5.2 (4.7-5.6) | 5.8 (5.5-6.1) | 5.2 (4.7-5.6) | ┼ | ┼ |