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Table 3 Rifampicin resistance-associated mutations detected in M. tuberculosis study isolates

From: Sequence analysis for detection of drug resistance in Mycobacterium tuberculosis complex isolates from the Central Region of Cameroon

Gene

N° and type of isolates tested

N° of isolates with indicated genotype

Nucleotide change

Amino acid change

rpoB

7 RIFR

5

531TCG → TTG

Ser → Leu

1

526CAC → GAC

His → Asp

1

516GAC → GTC

Asp → Val

 

100 RIFS

1

516GAC → TAC

Asp → Tyr

  1. NA = not applicable; WT = wild type; RIFR = rifampicin resistant isolate; RIFS = rifampicin sensitive isolate, N° = Number.