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Table 2 Isoniazid resistance- associated mutations detected in M. tuberculosis study isolates

From: Sequence analysis for detection of drug resistance in Mycobacterium tuberculosis complex isolates from the Central Region of Cameroon

Gene

N° of isolates tested

N° of isolates with indicated genotype

Nucleotide change

Amino acid change

N° of mutated isolates according to INH resistance level

     

Low level (0.2 μg/ml)

High level (1 μg/ml)

katG

44 INHR

18

315AGC → ACC

Ser → Thr

2

16

1

315AGC → AAC

Ser → Asn

0

1

1

Partial deletion

NA

0

1

 

24

WT

NA

0

0

100 INHS

0

WT

NA

NA

NA

fabG1-inhA regulatory region

44 INHR

13

-15C → T

NA

10

3

5

-47G → C

NA

0

5

 

26

WT

NA

0

0

100 INHS

24

-47G → C

NA

NA

NA

  

3

-102C → T

NA

NA

NA

  1. NA = not applicable; WT = wild type; INHR = isoniazid resistant isolate; INHS = isoniazid sensitive isolate; N°: number.