Table 2 Microarray analysis of the genes that were upregulated in one or both gatifloxacin-resistant mutants, 13124 ^R and NCTR ^R

Amino acid biosynthesis

CPE1520

CPF_1772 (ilvE)

branched-chain amino acid aminotransferase

1.1

2.6

CPE1905

CPF_2161 (dapA)

dihydrodipicolinate synthase

1.0

1.9

Cell envelope

CPE0492

CPF_0465

capsular polysaccharide biosynthesis protein

6.5

1.9

CPE0495

CPF_0468

UDP-glucose/GDP-mannose dehydrogenase family

3.5

2.4

CPE2059

CPF_2316

putative membrane protein

7.1

3.2

CPE2079

CPF_2336

putative membrane protein

14.2

2.1

CPE0785

CPF_0787

putative membrane protein

2.3

2.1

Energy metabolism

CPE2186

CPF_2451 (atpE)

ATP synthase epsilon subunit

3.3

2.9

CPE2187

CPF_2452 (atpB)

ATP synthase beta subunit

3.6

2.2

CPE2189

CPF_2454 (atpA)

ATP synthase alpha subunit

4.2

2.4

CPE2190

CPF_2455 (atpH)

ATP synthase delta subunit

1.9

2.1

CPE2191

CPF_2456 (atpF)

ATP synthase B chain

2.2

2.3

CPE2192

CPF_2457 (atpL)

ATP synthase C chain

3.6

2.3

Fatty acid and phospholipid metabolism

CPE1068

CPF_1324 (fabH)

3-oxoacyl-(acyl-carrier-protein) synthase III

2.2

4.7

CPE1069

CPF_1325 (fabD)

malonyl CoA-acyl carrier protein transacylase

1.1

3.6

CPE1071

CPF_1327 (fabF)

3-oxoacyl-(acyl-carrier-protein) synthase II

1.3

3.8

CPE1072

CPF_1328 (accB)

acetyl-CoA carboxylase, biotin carboxyl carrier

0.9

4.0

CPE1073

CPF_1329 (fabZ)

beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ

1.0

4.5

CPE1074

CPF_1330 (accC)

acetyl-CoA carboxylase, biotin carboxylase

1.7

4.9

CPE1075

CPF_1331 (accD)

acetyl-CoA carboxylase, carboxyl transferase, beta subunit

3.4

5.0

CPE1076

CPF_1332 (accA)

acetyl-CoA carboxylase, carboxyl transferase, alpha subunit

1.9

4.6

Protein synthesis

CPE1697

CPF_1951 (frr)

ribosome recycling factor

1.1

2.0

CPE2441

CPF_2720

ribosomal protein L7AE family

1.1

2.6

CPE2660

CPF_2997 (rpmH)

ribosomal protein L34

1.4

2.0

Purine, pyrimidine, nucleotides, and nucleosides

CPE1050

CPF_1305 (mtnH)

5-methylthioadenosine/S-adenosylhomocysteine nuclosidase

3.2

2.6

CPE2162

CPF_2418 (cpdC)

2`,3`-cyclic-nucleotide 2`-phosphodiesterase

3.4

1.6

Transport and binding proteins

CPE0977

CPF_1235

potassium transporter

7.1

2.9

Unknown functions

CPE2601

CPF_2928

conserved hypothetical protein

6.7

58.0