Table 2 MIC data for lacticin 3147, and its individual peptides Ltnα and Ltnβ, polymyxin B and polymyxin E alone and in combination

Lacticin 3147

Polymyxin B

Polymyxin E

Lacticin 3147/

FIC

Lacticin 3147/

FIC

Polymyxin B

Polymyxin E

231 (37.5 μM)

0.0586

0.0781

28.875/0.0073

0.250^a

28.875/ 0.0049

0.188^a

(α :124.74, Β: 106.26)

28.875 / 0.0147*

0.376*^a

14.4375 / 0.0195*

0.312*^a

Ltnα

Polymyxin B

Polymyxin E

Ltnα/

FIC

Ltnα/

FIC

Polymyxin B

Polymyxin E

187.11 (56.25 μM)

0.0586

0.0781

93.555 / 0.0073

0.625^b

46.7775/ 0.0195

0.500^a

(1.5 X Ltnα)

(6.0 X Ltnα in combin.)

(6.0 X Ltnα in combin.)

Ltnβ

Polymyxin B

Polymyxin E

Ltnβ/

FIC

Ltnβ/

FIC

Polymyxin B

Polymyxin E

495.88 (175 μM)

0.0586

0.0781

61.9850 / 0.0147

0.376^a

30.9925 / 0.0195

0.313^a

(4.7 X Ltnβ)

(4.7 X Ltnβ in combin.)

(4.7 X Ltnβ in combin.)