Figure 2

Q deficient worms respond to GD1 diet. (A) Wild-type (squares), coq-3(ok506) −/− (circles) and coq-3(qm188) −/− (diamonds) were fed either OP50 (black) (N2, n = 529; coq-3(ok506) −/−, n = 119; coq-3(qm188) −/−, n = 259) or GD1 (grey) (N2, n = 225; coq-3(ok506) −/−, n = 102; coq-3(qm188) −/−, n = 141) from the hatchling stage and assessed for survival. Asterisks designate: A significant increase in mean life span of N2 fed GD1 compared to OP50: 37% (p < .0001); Increase in mean life span of coq-3(ok506) −/− fed GD1 compared to N2 fed OP50: 58% (p < .0001); and Increase in mean life span of coq-3(qm188) −/− fed GD1 compared to N2 fed OP50: 74% (p < .0001). (B) Wild-type (squares) and coq-3(ok506) −/− (circles) were fed OP50 (black) until the L4 larval stage and then subsequently fed either OP50 (black) (N2, n = 63; coq-3(ok506) −/−, n = 84) or GD1 (grey) (N2, n = 55; coq-3(ok506) −/−, n = 53) and assessed for survival. Increase in mean life span of N2 worms fed GD1 compared to N2 fed OP50: 75% (p < .0001). Increase in mean life span of coq-3(ok506) −/− fed GD1 compared to N2 fed OP50: 113% (p < .0001). Data were subjected to one-way ANOVA with Fisher’s test at a significance level of p < 0.05.