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Table 2 Evaluation of the toxicity of the gomesin treatment

From: Therapeutic use of a cationic antimicrobial peptide from the spider Acanthoscurria gomesianain the control of experimental candidiasis

 

NINF*

NINF + GOM**

Leukocytes (mm3)

4637 ± 1114

4462 ± 1580

Neutrophils (mm3)

846 ± 288

1208 ± 388***

Eosinophils (mm3)

46 ± 46

135 ± 72***

Lymphocytes (mm3)

3744 ± 981

2660 ± 437***

Hemoglobin (g/dL)

13 ± 0.9

13 ± 0.5

Reticulocytes (%)

5.5 ± 0.7

9.3 ± 2.8***

Total Bilirubin (mg/dL)

0.48 ± 0.23

0.3 ± 0.1

Direct bilirubin (mg/dL)

0.35 ± 0.19

0.2 ± 0.1

Indirect bilirrubin (mg/dL)

0.13 ± 0.13

0.09 ± 0.009

Creatinine (mg/dL)

0.32 ± 0.09

0.34 ± 0.05

Gamma-GT (mg/dL)

< 1 U/L

< 1 U/L

  1. * Non-infected mice
  2. ** Non-infected mice treated with gomesin (GOM)
  3. *** p < 0.05
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BMC Microbiology

ISSN: 1471-2180

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