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Table 1 Burkholderia isolates used in this study.

From: Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis

Isolate

Description and reference

MIC (μg/ml kanamycin)

Virulence in mice by i.p. route

B. pseudomallei

   

K96243

Clinical isolate from Thailand, sequenced strain [26]

128

MLD = 262 (i.p.) [7]

576

Clinical isolate from Thailand [28]

128

MLD = 80 (i.p.) [7]

708a

Gentamicin-sensitive isolate from Thailand [9]

16

MLD = 2.3 × 103 (i.p.) [7]

B. thailandensis

   

E264

Environmental isolate, sequenced strain [10, 37]

128

1/10 survivors at 107 cfu [16]

Phuket 4W-1

Water isolate from Thailand [38]

128

2/10 survivors at 107 cfu [16]

CDC3015869

Clinical isolate from Texas; abbreviated as CDC301 [39]

128

8/10 survivors at 107 cfu [16]

CDC2721121

Clinical isolate from Louisiana; abbreviated as CDC272 [39]

128

10/10 survivors at 107 cfu [16]

B. oklahomensis

   

C6786

Clinical isolate from Oklahoma [40]

128

10/10 survivors at 107 cfu [16]

E0147

Clinical isolate from Georgia [41]

128

10/10 survivors at 107 cfu [16]

  1. Description of the Burkholderia strains used in this study, their susceptibility to kanamycin as described by the minimum inhibitory concentration (MIC) and a summary of published data on virulence of these isolates in mice described as the median lethal dose (MLD) in colony forming units or as number of survivors.