Figure 5

OprF-pulsed DCs protect mice from infection with the clinical isolate. Splenic DCs were pulsed and administered as in legend to figure 1. Mice were infected intranasally with 3 × 10⁷ P. aeruginosa mucoid strain. (A) Resistance to infection and (B) cytokine production in lung homogenates and culture supernatants of TLNs were assessed as in legend to Figure 2. * Indicates P < .05 (mice receiving pulsed versus unpulsed (-) DCs). In C - and + alone indicate uninfected and infected mice, respectively.