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Table 2 Putative proteins required for fungal virulence.

From: Transcriptional profiling reveals the expression of novel genes in response to various stimuli in the human dermatophyte Trichophyton rubrum

Accession no. of one EST

Library

Virulence determinant

Function in fungi

Reference number

FE526884

9

isocitrate lyase

Glyoxylate cycle enzyme

[43, 44]

FE525405

1

malate synthase

Glyoxylate cycle enzyme

[43, 44]

FE525119

1

citrate synthase

Glyoxylate cycle enzyme

[43, 44]

FE526004

4

phospholipase B

Gene inactivation attenuates virulence in Cryptococcus neoformans and Candida albicans

[63, 64]

FE526464

7

subtilisin-like protease Sub3

Sub3 is a dominant protease secreted by Trichophyton rubrum during host infection

[65]

FE526467

1, 7, 10

subtilisin-like protease Sub5

Putative Trichophyton rubrum virulence factor

[9]

FE526356

7

metalloprotease Mep3

MEP3 is produced by M. canis during guinea pigs infection

[66]

FE526553

7

metalloprotease Mep4

Mep4 is a dominant protease secreted by Trichophyton rubrum during host infection

[65]

FE526905

9

carboxypeptidase

Important for the assimilation of nitrogenous substrates during infection and contributes to the virulence of dermatophytes

[50]

FE524895

1

dipeptidyl-peptidase V

Dipeptidyl peptidases as potential virulence factors for Microsporum canis

[67]

FE526224

2, 7, 8

copper resistance-associated P-type ATPase

Cu-ATPase mutants showed reduced virulence in Listeria monocytogenes and Criptococcus neoformans

[52, 53, 68]

FE526598

2, 7, 8

Tru MDR2

Gene inactivation attenuates the virulence of Trichophyton rubrum in vitro

[40]

FE525063

1

mannosyltransferase

Gene inactivation attenuates the virulence of Candida albicans and Aspergillus fumigatus

[69, 70]

FE526454

7

urease

Gene inactivation reduces the amount of ammonia secreted in vitro and attenuates the virulence of Coccidioides posadasii

[32]

FE526352

1, 7

glucosamine-6-phosphate deaminase

Gene inactivation attenuates the virulence of Candida albicans in a murine model

[71]

FE524999

1

glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

GAPDH contributes to the adhesion of Paracoccidioides brasiliensis to host tissues and to the dissemination of infection.

[72]

FE527290

10

thioredoxin TrxA

Putative Trichophyton mentagrophytes virulence factor

[73]

  1. The overexpression of the ESTs from SSH libraries was confirmed by reverse Northern hybridization and/or Northern blot.