Accession no. of one EST | Library | Virulence determinant | Function in fungi | Reference number |
---|---|---|---|---|
FE526884 | 9 | isocitrate lyase | Glyoxylate cycle enzyme | |
FE525405 | 1 | malate synthase | Glyoxylate cycle enzyme | |
FE525119 | 1 | citrate synthase | Glyoxylate cycle enzyme | |
FE526004 | 4 | phospholipase B | Gene inactivation attenuates virulence in Cryptococcus neoformans and Candida albicans | |
FE526464 | 7 | subtilisin-like protease Sub3 | Sub3 is a dominant protease secreted by Trichophyton rubrum during host infection | [65] |
FE526467 | 1, 7, 10 | subtilisin-like protease Sub5 | Putative Trichophyton rubrum virulence factor | [9] |
FE526356 | 7 | metalloprotease Mep3 | MEP3 is produced by M. canis during guinea pigs infection | [66] |
FE526553 | 7 | metalloprotease Mep4 | Mep4 is a dominant protease secreted by Trichophyton rubrum during host infection | [65] |
FE526905 | 9 | carboxypeptidase | Important for the assimilation of nitrogenous substrates during infection and contributes to the virulence of dermatophytes | [50] |
FE524895 | 1 | dipeptidyl-peptidase V | Dipeptidyl peptidases as potential virulence factors for Microsporum canis | [67] |
FE526224 | 2, 7, 8 | copper resistance-associated P-type ATPase | Cu-ATPase mutants showed reduced virulence in Listeria monocytogenes and Criptococcus neoformans | |
FE526598 | 2, 7, 8 | Tru MDR2 | Gene inactivation attenuates the virulence of Trichophyton rubrum in vitro | [40] |
FE525063 | 1 | mannosyltransferase | Gene inactivation attenuates the virulence of Candida albicans and Aspergillus fumigatus | |
FE526454 | 7 | urease | Gene inactivation reduces the amount of ammonia secreted in vitro and attenuates the virulence of Coccidioides posadasii | [32] |
FE526352 | 1, 7 | glucosamine-6-phosphate deaminase | Gene inactivation attenuates the virulence of Candida albicans in a murine model | [71] |
FE524999 | 1 | glyceraldehyde-3-phosphate dehydrogenase (GAPDH) | GAPDH contributes to the adhesion of Paracoccidioides brasiliensis to host tissues and to the dissemination of infection. | [72] |
FE527290 | 10 | thioredoxin TrxA | Putative Trichophyton mentagrophytes virulence factor | [73] |