Figure 5
From: Rhomboid homologs in mycobacteria: insights from phylogeny and genomic analysis
The topology of mycobacterial rhomboids. Boxed (yellow) are the transmembrane domains containing the rhomboid catalytic residues and locations for the C-termini conserved residues. The Rv0110 mycobacterial orthologs formed topologies similar to those of the secretase eukaryotic rhomboid rho-1. The Rv1337 mycobacterial orthologs formed either six or five TMHs. The orthologs of pathogenic mycobcateria formed six TMHs while the orthologs of non-pathogenic mycobacteria formed five TMHs.