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Table 4 Variation in human proteins

From: Genetic variation in Staphylococcus aureus surface and immune evasion genes is lineage associated: implications for vaccine design and host-pathogen interactions

Ligand

Gene

NCBIGeneID

Variable amino acid sites

Proportion of variable sites

Characterised interacting S. aureus protein(s)

Elastin

eln

2006

40, 71,165, 298, 311, 398, 422, 463, 494, 503, 544, 581, 651, 711

0.019

EbpS, FnBPA

Fibrinogen/Fibrin

fga

2243

6, 331b, 392, 446, 456, 507, 729

0.010

ClfB, FnBPB, Ebh, IsdA,

 

fgb

2244

2, 86,100,170,192, 265, 398, 478

0.016

Efb,

 

fgg

2266

12,14, 25, 54, 77, 87, 89,113,114,132,140,177,191, 219, 410ac

0.033

ClfA, FnBPA

Fibronectin

fn-1

2335

15, 251c, 352, 759, 817, 984,1044,1103,1558, 2195, 2212, 2261, 2275, 2281

0.006

FnBPA, FnBPB,

Prothrombin

f2

2147

165, 200, 272, 386

0.006

VWbp

Vitronectin

vtn

7448

122, 268, 400

0.006

Unknown protein [118]

von Willebrand factor

vwf

7450

137, 318, 325d, 471, 484, 653, 740, 817, 852, 885,1380,1381,1435,1472,1565,1569, 2126, 2178, 2281, 2342, 2561, 2705

0.008

VWbp Spa

  1. a residues located in ClfA binding region [61].
  2. b residues located in ClfB binding region [64].
  3. c residues located in FnBPA binding region [91, 92].