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Table 1 Frequency of mutation at plasma antimicrobial concentrations in E. coli and Klebsiella spp.

From: In vitro selection of resistance in Escherichia coli and Klebsiella spp. at in vivo fluoroquinolone concentrations

Drug

Frequency of mutation

 

E. coli (n = 20)

Klebsiella spp . (n = 20)

 

Cmax

Cmin *

Cmax

Cmin*

LVX 500 mg

    

Range

<10-11

< 10-11 - 1.0 × 10-7

<10-11

<10-11 - 7.4 × 10-5

median

<10-11

2.0 × 10-11

<10-11

7.9 × 10-8

LVX 750 mg

    

Range

<10-11

<10-11 - 2.7 × 10-5

<10-11

<10-11 - 7.7 × 10-6

median

<10-11

<10-11

<10-11

2.2 × 10-8

CIP 500 mg

    

Range

<10-11

<10-11 - 6.3 × 10-6

<10-11

3.2 × 10-8 - 8.5 × 10-5

median

<10-11

<10-11

<10-11

1.5 × 10-7

PRU 600 mg

    

Range

<10-11 - 2.4 × 10-6

< 10-11 - 4.1 × 10-6

<10-11 - 1.7 × 10-5

6.3 × 10-9- 2.2 × 10-5

median

4.3 × 10-8

2.4 × 10-7

6.7 × 10-9

7.1 × 10-7

  1. LVX: Levofloxacin; CIP: Ciprofloxacin; PRU: Prulifloxacin; Cmax: peak plasma concentration; Cmin: trough plasma concentration
  2. * Frequency of mutations was calculated only for strains with MIC < Cmin.
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BMC Microbiology

ISSN: 1471-2180

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